View bacteriocin : Plantaricin-A

 Bookmark and Share

Accession BAC022
Name Plantaricin-A
Related Entries plantaricin JPlantaricin S βPlantaricin S αplantaricin Kplantaricin E

plantaricin FPlantaricin C19Plantaricin NC8 αPlantaricin NC8 βPlantaricin 423

Plantaricin W αPlantaricin W βPlantaricin 1.25 βPlantaricin ASM1
Gene plnA; OrderedLocusNames=lp_0415
Class Unclassified
Producer Organism Lactobacillus plantarum [Gram-positive]
Taxonomy BacteriaFirmicutesLactobacillalesLactobacillaceaeLactobacillus
Target organisms closely related Lactobacillus {species}
Swiss-Prot Entry P80214
PDB Entry 1YTR resolved by NMR. Structure in dpc micelles
Other databases EMBL X75323EMBL X94434EMBL AL935253PIR A45913GenomeReviews AL935263_GR

BioCyc LPLA220668:LP_0415-MONOMERInterPro IPR010133TIGRFAMs TIGR01847
Description Mode of action:
This heat stable bacteriocin, may act as a pore- forming protein, creating a channel in the cell membrane through a "barrel stave" mechanism. beta chain.
[Ref. 1] | View abstract | Export citation
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=C11
MEDLINE=94161498;PubMed=8117074;
Diep B.D., Havarstein L.S., Nissen-Meyer J., Nes F.I.
"The gene encoding plantaricin A, a bacteriocin from Lactobacillus plantarum C11, is located on the same transcription unit as an agr- like regulatory system.", Appl. Environ. Microbiol. 60:160-166(1994).

[Ref. 2] | View abstract | Export citation
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=C11
MEDLINE=96345611;PubMed=8755874;
Diep D.B., Havarstein L.S., Nes I.F.
"Characterization of the locus responsible for the bacteriocin production in Lactobacillus plantarum C11.", J. Bacteriol. 178:4472-4483(1996).

[Ref. 3] | View abstract | Export citation
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], STRAIN=NCIMB 8826 / WCFS1
MEDLINE=22480296;PubMed=12566566;DOI=10.1073/pnas.0337704100
Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing
"Complete genome sequence of Lactobacillus plantarum WCFS1", Proc. Natl. Acad. Sci. U.S.A. 100 (4):1990-5 (2003).

[Ref. 4] | View abstract | Export citation
PROTEIN SEQUENCE OF 26-47, STRAIN=C11
MEDLINE=94065628;PubMed=8245827;
Nissen-Meyer J., Granly Larsen A.G., Sletten K., Daeschel M., Nes I.F.
"Purification and characterization of plantaricin A, a Lactobacillus plantarum bacteriocin whose activity depends on the action of two peptides.", J. Gen. Microbiol. 139:1973-1978(1993).

Loading...
End Note
Reference Manager
BibTeX
Sequence
 ........10 ........20 ........30 
          |          |          | 
 AYSLQMGATA IKQVKKLFKK WGW
Wheel representation
Structure
Composition
Formula C128 H200 N32 O29 S1
Absent amino acids CDEHNPR
Common amino acids K
Mass (Da) 2701.64
Net charge +5
Isoelectric point 11.02
Basic residues 5
Acidic residues 0
Hydrophobic residues 10
Polar residues 5
Aliphatic residues 4
Tiny residues 6
Boman Index -8.84
Hydropathy Index -0.24
Aliphatic Index 76.52
Instability Index 12.75 (stable)
Half Life Mammalian : 4.4 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 12490 M-1 cm-1
Absorbance 280nm 567.73
Red solid plot : values according to the hydrophobicity scale of Kyte and Doolittle (reference paper).


Yellow dashed plot : Experimentally determined hydrophobicity scale for proteins at membrane interfaces(reference paper).


Green dotted-dashed plot : prediction of transmembrane helices (reference paper). In this scale (unlike the others), more negative values reflect greater hydrophobicity.

Users comments for Plantaricin-A

No comments found

Login or register to submit a comment for Plantaricin-A.