View bacteriocin : Enterocin Q

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Accession BAC052
Name Enterocin Q
Related Entries Enterocin PEnterocin I (Enterocin L50A)Enterocin AEnterocin BEnterocin 1071A

Enterocin CRL35 (Mundticin KS)Enterocin SE-K4Enterocin AS-48 (BACTERIOCIN AS-48)Enterocin 96Enterocin E-760

Enterocin-HFEnterocin XalphaEnterocin XbetaEnterocin EJ97
Gene entQ
Class Class IIc
Producer Organism Enterococcus faecium (Streptococcus faecium) [Gram-positive]
Taxonomy BacteriaFirmicutesLactobacillalesEnterococcaceaeEnterococcus
Target organisms Lactobacillus sakei - Enterococcus faecium
Swiss-Prot Entry Q7WYZ9
PDB Entry Unknown
Other databases EMBL AY318955
Description Enterococcus faecium L50 produces, in addition to EntL50, the sec-dependent pediocin-like enterocin P (EntP), and an unmodified non-pediocin-like bacteriocin, termed enterocin Q (EntQ), synthesized without an N-terminal leader sequence or signal peptide. Note=Ref1.
[Ref. 1] | View abstract | Export citation
NUCLEOTIDE SEQUENCE, STRAIN=L50
MEDLINE=20528333;PubMed=11073927;DOI=10.1128/JB.182.23.6806-6814.2000
Cintas L.M., Casaus P., Herranz C., Havarstein L.S., Holo H., Hernandez P.E., Nes I.F.
"Biochemical and genetic evidence that Enterococcus faecium L50 produces enterocins L50A and L50B, the sec-dependent enterocin P, and a novel bacteriocin secreted without an N-terminal extension termed enterocin Q.", J. Bacteriol. 182:6806-6814(2000).

[Ref. 2]
NUCLEOTIDE SEQUENCE, STRAIN=L50
Cintas L.M., Casaus P., Herranz C., Havarstein L.S., Holo H., Hernandez P.E., Nes I.F.
"", Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.

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Sequence
 ........10 ........20 ........30 ........40 
          |          |          |          | 
 MNFLKNGIAK WMTGAELQAY KKKYGCLPWE KISC
Wheel representation
Composition
Formula C181 H281 N45 O46 S4
Absent amino acids DHRV
Common amino acids K
Mass (Da) 3970.31
Net charge +4
Isoelectric point 9.78
Basic residues 6
Acidic residues 2
Hydrophobic residues 11
Polar residues 11
Aliphatic residues 5
Tiny residues 7
Boman Index -24.24
Hydropathy Index -0.36
Aliphatic Index 66.18
Instability Index 21.66 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 14105 M-1 cm-1
Absorbance 280nm 427.42
Red solid plot : values according to the hydrophobicity scale of Kyte and Doolittle (reference paper).


Yellow dashed plot : Experimentally determined hydrophobicity scale for proteins at membrane interfaces(reference paper).


Green dotted-dashed plot : prediction of transmembrane helices (reference paper). In this scale (unlike the others), more negative values reflect greater hydrophobicity.

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