View bacteriocin : Enterocin P

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Accession BAC079
Name Enterocin P
Related Entries Enterocin QEnterocin I (Enterocin L50A)Enterocin AEnterocin BEnterocin 1071A

Enterocin CRL35 (Mundticin KS)Enterocin SE-K4Enterocin AS-48 (BACTERIOCIN AS-48)Enterocin 96Enterocin E-760

Enterocin-HFEnterocin XalphaEnterocin XbetaEnterocin EJ97
Gene entP
Class Class IIa, IIb and IIc (problematic)
Producer Organism Enterococcus faecium (Streptococcus faecium) [Gram-positive]
Taxonomy BacteriaFirmicutesLactobacillalesEnterococcaceaeEnterococcus
Target organisms Lactobacillus sakei - Enterococcus faecium
Swiss-Prot Entry O30434
PDB Entry Unknown
Other databases EMBL AF005726HSSP P38580GO GO:0005576GO GO:0042742InterPro IPR002633

Pfam PF01721ProDom PD004452
Description Enterococcus faecium L50 produces, in addition to EntL50, the sec-dependent pediocin-like enterocin P (EntP), and an unmodified non-pediocin-like bacteriocin, termed enterocin Q (EntQ), synthesized without an N-terminal leader sequence or signal peptide. Note=Ref2.

Classification note:
Enterocin P classification is problematic since it classified in class IIa, IIb and IIc according to literature. To review its classification, please see Zouhir et al., 2007.
[Ref. 1] | View abstract | Export citation
NUCLEOTIDE SEQUENCE, STRAIN=L50
MEDLINE=20528333;PubMed=11073927;DOI=10.1128/JB.182.23.6806-6814.2000
Cintas L.M., Casaus P., Herranz C., Havarstein L.S., Holo H., Hernandez P.E., Nes I.F.
"Biochemical and genetic evidence that Enterococcus faecium L50 produces enterocins L50A and L50B, the sec-dependent enterocin P, and a novel bacteriocin secreted without an N-terminal extension termed enterocin Q.", J. Bacteriol. 182:6806-6814(2000).

[Ref. 2] | View abstract | Export citation
NUCLEOTIDE SEQUENCE, STRAIN=P13
MEDLINE=98027370;PubMed=9361419;
Cintas L.M., Casaus P., Havarstein L.S., Hernandez P.E., Nes I.F.
"Biochemical and genetic characterization of enterocin P, a novel sec- dependent bacteriocin from Enterococcus faecium P13 with a broad antimicrobial spectrum.", Appl. Environ. Microbiol. 63:4321-4330(1997).

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Sequence
 ........10 ........20 ........30 ........40 ........50 
          |          |          |          |          | 
 ATRSYGNGVY CNNSKCWVNW GEAKENIAGI VISGWASGLA GMGH
Wheel representation
Composition
Formula C202 H303 N59 O61 S3
Absent amino acids DFPQ
Common amino acids G
Mass (Da) 4648.91
Net charge +2
Isoelectric point 8.22
Basic residues 4
Acidic residues 2
Hydrophobic residues 15
Polar residues 22
Aliphatic residues 7
Tiny residues 17
Boman Index -33.68
Hydropathy Index -0.15
Aliphatic Index 66.59
Instability Index 13.31 (stable)
Half Life Mammalian : 4.4 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 19605 M-1 cm-1
Absorbance 280nm 455.93
Red solid plot : values according to the hydrophobicity scale of Kyte and Doolittle (reference paper).


Yellow dashed plot : Experimentally determined hydrophobicity scale for proteins at membrane interfaces(reference paper).


Green dotted-dashed plot : prediction of transmembrane helices (reference paper). In this scale (unlike the others), more negative values reflect greater hydrophobicity.

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