View bacteriocin : Microcin H47

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Accession BAC110
Name Microcin H47
Related Entries Microcin J25microcin B17 (MccB17)Microcin E492Colicin-V (Microcin-V)Microcin-24

Microcin C7
Gene mchB
Class Unclassified
Producer Organism Escherichia coli [Gram-negative]
Taxonomy BacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Target organisms Active on bacteria phylogenetically related to the producing strain.
Swiss-Prot Entry P62530 Q9RM53
PDB Entry Unknown
Other databases EMBL AJ009631
Description Mode of action:
Bactericidal antibiotic. ABC transporter system.
[Ref. 1] | View abstract | Export citation
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=H47
MEDLINE=99402674;PubMed=10471561;
Rodriguez E., Gaggero C., Lavina M.
"The structural gene for microcin H47 encodes a peptide precursor with antibiotic activity.", Antimicrob. Agents Chemother. 43:2176-2182(1999).

[Ref. 2] | View abstract | Export citation
CHARACTERIZATION, STRAIN=H47
MEDLINE=21091907;PubMed=11181394;DOI=10.1128/AAC.45.3.969-972.2001
Azpiroz M.F., Rodriguez E., Lavina M.
"The structure, function, and origin of the microcin H47 ATP-binding cassette exporter indicate its relatedness to that of colicin V.", Antimicrob. Agents Chemother. 45:969-972(2001).

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Sequence
 ........10 ........20 ........30 ........40 ........50 ........60 ........70 
          |          |          |          |          |          |          | 
 GGAPATSANA AGAAAIVGAL AGIPGGPLGV VVGAVSAGLT TAIGSTVGSG SASSSAGGGS
Wheel representation
Composition
Formula C205 H345 N61 O75
Absent amino acids CDEFHKMQRWY
Common amino acids GA
Mass (Da) 4883.4
Net charge 0
Isoelectric point 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 27
Polar residues 30
Aliphatic residues 12
Tiny residues 40
Boman Index 48.43
Hydropathy Index 0.87
Aliphatic Index 93
Instability Index 17.69 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 0 M-1 cm-1
Absorbance 280nm 0
Red solid plot : values according to the hydrophobicity scale of Kyte and Doolittle (reference paper).


Yellow dashed plot : Experimentally determined hydrophobicity scale for proteins at membrane interfaces(reference paper).


Green dotted-dashed plot : prediction of transmembrane helices (reference paper). In this scale (unlike the others), more negative values reflect greater hydrophobicity.

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