View bacteriocin : Halocin H4

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Accession BAC125
Name Halocin H4
Related Entries Halocin-C8Halocin-S8
Gene HALH4
Class Unclassified
Producer Organism Halobacterium mediterranei (Haloferax mediterranei) [Gram-]
Taxonomy ArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloferax
Target organisms Unavailable data
Swiss-Prot Entry Q48236
PDB Entry Unknown
Other databases EMBL U16389
Description Has antibacterial activity against other haloarchaeons. Interacts with the membrane of the target cells where it causes permeability changes that result in an ionic imbalance leading to cell lysis and death.
[Ref. 1] | View abstract | Export citation
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE. STRAIN=ATCC 33500 / R4
MEDLINE=97144544;PubMed=8990311;
Cheung J., Danna K.J., O'Connor E.M., Price L.B., Shand R.F.;
"Isolation, sequence, and expression of the gene encoding halocin H4,a bacteriocin from the halophilic archaeon Haloferax mediterranei R4.", J. Bacteriol. 179:548-551(1997).

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Sequence
 ........10 ........20 ........30 ........40 ........50 ........60 ........70 ........80 
          |          |          |          |          |          |          |          | 
 DIAPPGPNGD PKSVQIDDKY TGAEMYGEGD FRVGLGTDLT MYPPVYRESL GNGSGGWEFD FTVCGSTACR FVDSNGDVKE
 DDKAKEMWWQ EINFNDINQD LYSRNDSDWV GSTPADTQPE FDYTDFALAR DGVTLALTAL NPAMGSLALG ATYFLSDMVN
 WIASQHEDDS SLKRKWDYDG LSGPLYADSS TYLLARDEMT SNSYESFTID NIAVAFPEFP VRTKYYVTFT APDDPSTQSI
 STLEEEGIYR VPATE
Composition
Formula C1253 H1855 N315 O419 S8
Absent amino acids -
Common amino acids D
Mass (Da) 28294.8
Net charge -27
Isoelectric point 3.81
Basic residues 18
Acidic residues 45
Hydrophobic residues 76
Polar residues 89
Aliphatic residues 39
Tiny residues 61
Boman Index -479.59
Hydropathy Index -0.53
Aliphatic Index 8.01
Instability Index 35.68 (stable)
Half Life Mammalian : 1.1 hour
Yeast : 3 min
E. coli : >10 hour
Extinction Coefficient 56840 M-1 cm-1
Absorbance 280nm 182.58
Red solid plot : values according to the hydrophobicity scale of Kyte and Doolittle (reference paper).


Yellow dashed plot : Experimentally determined hydrophobicity scale for proteins at membrane interfaces(reference paper).


Green dotted-dashed plot : prediction of transmembrane helices (reference paper). In this scale (unlike the others), more negative values reflect greater hydrophobicity.

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