Bacteriocin: Nisin Q

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Bacteriocin: Nisin Q

Accession: BAC145

Class: Lantibiotic
Gene: nisQ
Producer and target organisms

Producer Organism: Lactococcus lactis [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesStreptococcaceaeLactococcus

Target organismswide range of Gram-positive bacteria including LAB - Bacillus sp - Listeria sp - Micrococcus sp -

Note:The antibacterial spectrum is similar to that of nisins A & Z(not completely identical)

Mode of action:
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor. plasmid DNA. The sequences reported are absolutely identical.
Uniprot and PDB links

UniProt Entry: Q76HP8

PDB EntryUnknown

Zendo T., Fukao M., Ueda K., Higuchi T., Nakayama J., Sonomoto K.
"Identification of the lantibiotic nisin Q, a new natural nisinvariant produced by Lactococcus lactis 61-14 isolated from a river in Japan.", Biosci. Biotechnol. Biochem. 67:1616-1619 (2003).
Yoneyama F., Fukao M., Zendo T., Nakayama J., Sonomoto K.
"Biosynthetic characterization and biochemical features of the third natural nisin variant, nisin Q, produced by Lactococcus lactis 61-14.", J. Appl. Microbiol. 105:1982-1990 (2008).
End Note
Reference Manager
Gene structure
genome of Nisin Q

Gene idNameDescriptionLocation
BACGene642nisQnisin Q precursor173..346
BACGene643niqBlantibiotic dehydratase453..3434
BACGene644niqTATP-binding cassette transporter3445..5247
BACGene645niqClantibiotic cyclase5240..6481
BACGene646niqIimmunity protein self-protection6478..7215
BACGene647niqPleader peptidase7217..9304
BACGene648niqRresponse regulator9370..10056
BACGene649niqKhistidine kinase10049..11392
BACGene650niqFimmunity protein self-protection11490..12167
BACGene651niqEimmunity protein self-protection12169..12897
BACGene652niqGimmunity protein self-protection12884..13528
Protein sequence
 ........10 ........20 ........30 ........40 
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Wheel representation
wheel representation of Nisin Q

Formula C143 H249 N41 O46 S6
Absent amino acids DEFQRWY
Common amino acids CT
Mass (Da) 3489.73
Net charge +4
Isoelectric point 8.51
Basic residues 4
Acidic residues 0
Hydrophobic residues 9
Polar residues 19
Aliphatic residues 8
Tiny residues 8
Boman Index -10.94
Hydropathy Index 0.52
Aliphatic Index 85.88
Instability Index 13.45 (stable)
Half Life Mammalian : 20 hour
Yeast : 30 min
E. coli : >10 hour
Extinction Coefficient 0 M-1 cm-1
Absorbance 280nm 7.68

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