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View bacteriocin : Nisin Q

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Accession BAC145
Name Nisin Q
Related Entries Nisin ANisin ZNisin Fnisin U
Gene nisQ
Class Lantibiotic
Producer Organism Lactococcus lactis [Gram-positive]
Taxonomy BacteriaFirmicutesLactobacillalesStreptococcaceaeLactococcus
Target organisms wide range of Gram-positive bacteria including LAB - Bacillus sp - Listeria sp - Micrococcus sp -

Note:The antibacterial spectrum is similar to that of nisins A & Z(not completely identical)
Swiss-Prot Entry Q76HP8
PDB Entry Unknown
Other databases EMBL AB100029EMBL AB362350ProteinModelPortal Q76HP8SMR Q76HP8GO GO:0050830

InterPro IPR006079InterPro IPR000446Pfam PF02052PRINTS PR00324TIGRFAMs TIGR03731

Description Mode of action:
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor. plasmid DNA. The sequences reported are absolutely identical.
[Ref. 1] | View abstract | Export citation
NUCLEOTIDE SEQUENCE, STRAIN=61-14
MEDLINE=22793497;PubMed=12913315;DOI=10.1271/bbb.67.1616
Zendo T., Fukao M., Ueda K., Higuchi T., Nakayama J., Sonomoto K.
"Identification of the lantibiotic nisin Q, a new natural nisinvariant produced by Lactococcus lactis 61-14 isolated from a river in Japan.", Biosci. Biotechnol. Biochem. 67:1616-1619 (2003).

[Ref. 2] | View abstract | Export citation
NUCLEOTIDE SEQUENCE, STRAIN=61-14
PubMed=19120645;DOI=10.1111/j.1365-2672.2008.03958.x
Yoneyama F., Fukao M., Zendo T., Nakayama J., Sonomoto K.
"Biosynthetic characterization and biochemical features of the third natural nisin variant, nisin Q, produced by Lactococcus lactis 61-14.", J. Appl. Microbiol. 105:1982-1990 (2008).

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Sequence
 ........10 ........20 ........30 ........40 
          |          |          |          | 
 ITSISLCTPG CKTGVLMGCN LKTATCNCSV HVSK

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Composition
Formula C143 H249 N41 O46 S6
Absent amino acids DEFQRWY
Common amino acids CT
Mass (Da) 3489.73
Net charge +4
Isoelectric point 8.51
Basic residues 4
Acidic residues 0
Hydrophobic residues 9
Polar residues 19
Aliphatic residues 8
Tiny residues 8
Boman Index -10.94
Hydropathy Index 0.52
Aliphatic Index 85.88
Instability Index 13.45 (stable)
Half Life Mammalian : 20 hour
Yeast : 30 min
E. coli : >10 hour
Extinction Coefficient 0 M-1 cm-1
Absorbance 280nm 7.68
Red solid plot : values according to the hydrophobicity scale of Kyte and Doolittle (reference paper).


Yellow dashed plot : Experimentally determined hydrophobicity scale for proteins at membrane interfaces(reference paper).


Green dotted-dashed plot : prediction of transmembrane helices (reference paper). In this scale (unlike the others), more negative values reflect greater hydrophobicity.

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