View bacteriocin : carnocin UI49 Bookmark and Share

Accession BAC001
Name carnocin UI49
Related Entries carnobacteriocin B2 (Carnocin CP52)
Gene Unidentified
Class lantibiotic
Producer Organism Carnobacterium sp (strain UI49) [Gram-positive]
Taxonomy BacteriaFirmicutesLactobacillalesCarnobacteriaceaeCarnobacterium
Target organisms Carnobacteria - Lactobacilli - Pediococci - Lactococci
Swiss-Prot Entry P36960
PDB Entry Unknown
Description Mode of action:
Lanthionine-containing peptide antibiotic (lantibiotic). Active on Gram-positive bacteria.
[Ref. 1] | View abstract | Export citation
PROTEIN SEQUENCE.
MEDLINE=92321768;PubMed=1622206;
Stoffels G., Nissen-Meyer J., Gudmundsdottir A., Sletten K., Holo H., Nes I.F.
"Purification and characterization of a new bacteriocin isolated from a Carnobacterium sp.", Appl. Environ. Microbiol. 58:1417-1422(1992).

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Sequence
........10
|
GSEIQPR

Warning: partial sequence.
Wheel representation
Composition
AA N° %

AA N° %

AA N° %
Ala 0 .00%

Ile 1 14.29%

Arg 1 14.29%
Cys 0 .00%

Lys 0 .00%

Ser 1 14.29%
Asp 0 .00%

Leu 0 .00%

Thr 0 .00%
Glu 1 14.29%

Met 0 .00%

Val 0 .00%
Phe 0 .00%

Asn 0 .00%

Trp 0 .00%
Gly 1 14.29%

Pro 1 14.29%

Tyr 0 .00%
His 0 .00%

Gln 1 14.29%
Total 7
Formula C32 H55 N11 O12
Absent amino acids ACDFHKLMNTVWY
Common amino acids EGIPQRS
Mass (Da) 803.95
Net charge 0
Isoelectric point 6.41
Basic residues 1
Acidic residues 1
Hydrophobic residues 1
Polar residues 2
Aliphatic residues 1
Tiny residues 2
Boman Index -24.81
Hydropathy Index -1.4
Aliphatic Index 55.71
Instability Index 80.34 (unstable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 0 M-1 cm-1
Absorbance 280nm 0
Red solid plot : values according to the hydrophobicity scale of Kyte and Doolittle (reference paper).


Yellow dashed plot : Experimentally determined hydrophobicity scale for proteins at membrane interfaces(reference paper).


Green dotted-dashed plot : prediction of transmembrane helices (reference paper). In this scale (unlike the others), more negative values reflect greater hydrophobicity.

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