View bacteriocin : Halocin-C8 Bookmark and Share

Accession BAC008
Name Halocin-C8
Related Entries Halocin-S8Halocin H4
Gene Unidentified
Class Unclassified
Producer Organism Halobacterium sp (strain AS7092) [Gram-]
Taxonomy ArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Target organisms wide variety of haloarchaeons
Swiss-Prot Entry P83716
PDB Entry Unknown
Other databases GO GO:0005576GO GO:0042742
Description Mode of action:
Causes cell lysis and death, possibly by disrupting the cell wall. boiled, subjected to organic solvents, and stored at 4 degrees Celsius for extended periods without losing activity.
[Ref. 1] | View abstract | Export citation
PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=12811620;DOI=10.1007/s00792-003-0335-6
Li Y., Xiang H., Liu J., Zhou M., Tan H.
"Purification and biological characterization of halocin C8, a novel peptide antibiotic from Halobacterium strain AS7092.", Extremophiles 7:401-407(2003).

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Sequence
........10........20
| |
DIDITGCSACKYAAG
Wheel representation
Composition
AA N° %

AA N° %

AA N° %
Ala 3 20.00%

Ile 2 13.33%

Arg 0 .00%
Cys 2 13.33%

Lys 1 6.67%

Ser 1 6.67%
Asp 2 13.33%

Leu 0 .00%

Thr 1 6.67%
Glu 0 .00%

Met 0 .00%

Val 0 .00%
Phe 0 .00%

Asn 0 .00%

Trp 0 .00%
Gly 2 13.33%

Pro 0 .00%

Tyr 1 6.67%
His 0 .00%

Gln 0 .00%
Total 15
Formula C61 H98 N16 O23 S2
Absent amino acids EFHLMNPQRVW
Common amino acids A
Mass (Da) 1505.93
Net charge -1
Isoelectric point 4.11
Basic residues 1
Acidic residues 2
Hydrophobic residues 5
Polar residues 7
Aliphatic residues 2
Tiny residues 6
Boman Index -9.39
Hydropathy Index 0.33
Aliphatic Index 72
Instability Index 48.75 (unstable)
Half Life Mammalian : 1.1 hour
Yeast : 3 min
E. coli : >10 hour
Extinction Coefficient 1615 M-1 cm-1
Absorbance 280nm 115.36
Red solid plot : values according to the hydrophobicity scale of Kyte and Doolittle (reference paper).


Yellow dashed plot : Experimentally determined hydrophobicity scale for proteins at membrane interfaces(reference paper).


Green dotted-dashed plot : prediction of transmembrane helices (reference paper). In this scale (unlike the others), more negative values reflect greater hydrophobicity.

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