View bacteriocin : pediocin PA-1 (Pediocin ACH) Bookmark and Share

Accession BAC083
Name pediocin PA-1 (Pediocin ACH)
Gene pedA; Synonyms=pap, papA
Class class IIA/YGNGV
Producer Organism Pediococcus acidilactici [Gram-positive]
Taxonomy BacteriaFirmicutesLactobacillalesLactobacillaceaePediococcus
Target organisms Pediococci - Lactobacilli - Leuconostocs - Brochothrix thermosphacta - propionibacteria - Bacilli - Enterococci - Staphylococci - Listeria clostridia - Listeria monocytogenes - Listeria innocua
Swiss-Prot Entry P29430 P34912
PDB Entry Unknown
Other databases EMBL M83924EMBL M90679EMBL U02482PIR A48941HSSP P34034

InterPro IPR002633InterPro IPR010133Pfam PF01721ProDom PD004452TIGRFAMs TIGR01847
Description Mode of action:
Bactericidal activity (effective inhibitor of Listeria monocytogenes).
[Ref. 1] | View abstract | Export citation
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=PAC-1.0; PLASMID=pSRQ11
MEDLINE=92384551;PubMed=1514784;
Marugg J.D., Gonzalez C.F., Kunka B.S., Ledeboer A.M., Pucci M.J., Toonen M.Y., Walker S.A., Zoetmulder L.C.M., Vandenbergh P.A.
"Cloning, expression, and nucleotide sequence of genes involved in production of pediocin PA-1, and bacteriocin from Pediococcus acidilactici PAC1.0.", Appl. Environ. Microbiol. 58:2360-2367(1992).

[Ref. 2] | View abstract | Export citation
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=H; PLASMID=pSMB74
MEDLINE=94288967;PubMed=7764941;
Motlagh A.M., Bukhtiyarova M.B., Ray B.R.
"Complete nucleotide sequence of pSMB 74, a plasmid encoding the production of pediocin AcH in Pediococcus acidilactici.", Lett. Appl. Microbiol. 18:305-312(1994).

[Ref. 3] | View abstract | Export citation
PROTEIN SEQUENCE OF 19-62, AND DISULFIDE BONDS, STRAIN=PAC-1.0; PLASMID=pSRQ11
MEDLINE=92246549;PubMed=1575516;
Henderson J.T., Chopko A.L., van Wassenaar P.D.
"Purification and primary structure of pediocin PA-1 produced by Pediococcus acidilactici PAC-1.0.", Arch. Biochem. Biophys. 295:5-12(1992).

[Ref. 4] | View abstract | Export citation
PROTEIN SEQUENCE OF 19-61.
MEDLINE=93019000;PubMed=1402795;
Lozano J.C.N., Meyer J.N., Sletten K., Pelaz C., Nes I.F.
"Purification and amino acid sequence of a bacteriocin produced by Pediococcus acidilactici.", J. Gen. Microbiol. 138:1985-1990(1992).

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Sequence
........10........20........30........40........50
| | | | |
KYYGNGVTCGKHSCSVDWGKATTCIINNGAMAWATGGHQGNHKC
Wheel representation
Composition
AA N° %

AA N° %

AA N° %
Ala 4 9.09%

Ile 2 4.55%

Arg 0 .00%
Cys 4 9.09%

Lys 4 9.09%

Ser 2 4.55%
Asp 1 2.27%

Leu 0 .00%

Thr 4 9.09%
Glu 0 .00%

Met 1 2.27%

Val 2 4.55%
Phe 0 .00%

Asn 4 9.09%

Trp 2 4.55%
Gly 8 18.18%

Pro 0 .00%

Tyr 2 4.55%
His 3 6.82%

Gln 1 2.27%
Total 44
Formula C196 H297 N61 O60 S5
Absent amino acids EFLPR
Common amino acids G
Mass (Da) 4646.95
Net charge +6
Isoelectric point 8.67
Basic residues 7
Acidic residues 1
Hydrophobic residues 10
Polar residues 24
Aliphatic residues 4
Tiny residues 14
Boman Index -49.55
Hydropathy Index -0.49
Aliphatic Index 40
Instability Index -0.48 (stable)
Half Life Mammalian : 1.3 hour
Yeast : 3 min
E. coli : 2 min
Extinction Coefficient 14230 M-1 cm-1
Absorbance 280nm 330.93
Red solid plot : values according to the hydrophobicity scale of Kyte and Doolittle (reference paper).


Yellow dashed plot : Experimentally determined hydrophobicity scale for proteins at membrane interfaces(reference paper).


Green dotted-dashed plot : prediction of transmembrane helices (reference paper). In this scale (unlike the others), more negative values reflect greater hydrophobicity.

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