BACTIBASE Database : Thiocillin (Micrococcin P1) (Micrococcin P2) (Thiocillin I) (Thiocillin II) (Thiocillin III) (Thiocillin IV) (Antibiotic YM-266183) (Antibiotic YM-266184) details

View bacteriocin : Thiocillin (Micrococcin P1) (Micrococcin P2) (Thiocillin I) (Thiocillin II) (Thiocillin III) (Thiocillin IV) (Antibiotic YM-266183) (Antibiotic YM-266184)

General data
References
Structural data
Physicochemical data
Comments

Accession	BAC171
Name	Thiocillin (Micrococcin P1) (Micrococcin P2) (Thiocillin I) (Thiocillin II) (Thiocillin III) (Thiocillin IV) (Antibiotic YM-266183) (Antibiotic YM-266184)
Gene	~~Unidentified~~
Class	~~Unclassified~~
Producer Organism	Bacillus cereus (strain ATCC 14579 / DSM 31) [Gram-positive]
Taxonomy	BacteriaFirmicutesBacillalesBacillaceaeBacillusBacillus cereus group
Target organisms	Bacillus subtilis PCI219 - Bacillus anthracis - Staphylococcus aureus FDA209P - Staphylococcus aureus Smith - Staphylococcus aureus 80257 - Streptococcus pyogenes C-203 - Streptococcus pneumoniae type D - note: not active against Gram-negative bacteria
Swiss-Prot Entry	Q812G9
PDB Entry	~~Unknown~~
Other databases	*EMBL* AE016877 *EMBL* AE016877 *EMBL* AE016877 *EMBL* AE016877 *RefSeq* NP_834755.1 *RefSeq* NP_834756.1 *RefSeq* NP_834757.1 *RefSeq* NP_834758.1 *GeneID* 1207428 *GeneID* 1207429 *GeneID* 1207430 *GeneID* 1207431 *GenomeReviews* AE016877_GR *GenomeReviews* AE016877_GR *GenomeReviews* AE016877_GR *GenomeReviews* AE016877_GR *KEGG* bce:BC5087 *KEGG* bce:BC5088 *KEGG* bce:BC5089 *KEGG* bce:BC5090 *HOGENOM* Q812G9 *BioCyc* BCER226900:BC_5087-MON *BioCyc* BCER226900:BC_5088-MON *BioCyc* BCER226900:BC_5089-MON *BioCyc* BCER226900:BC_5090-MON GO GO:0005576 GO GO:0005102 GO GO:0019835 GO GO:0042742

[Ref. 1] | View abstract | Export citation

POST-TRANSLATIONAL MODIFICATIONS.
PubMed=19196969;DOI=10.1073/pnas.0900008106
Brown L.C.W., Acker M.G., Clardy J., Walsh C.T., Fischbach M.A.;"
"Thirteen posttranslational modifications convert a 14-residue peptideinto the antibiotic thiocillin.";", Proc. Natl. Acad. Sci. U.S.A. 106:2549-2553(2009)

[Ref. 2] | View abstract | Export citation

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
MEDLINE=22608415;PubMed=12721630;DOI=10.1038/nature01582
Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G., Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.
"Genome sequence of Bacillus cereus and comparative analysis withBacillus anthracis", Nature 423:87-91(2003)

[Ref. 3] | View abstract | Export citation

PubMed=819410;
Shoji, J., Hinoo, H., Wakisaka, Y., Koizumi, K., and Mayama, M.
"Isolation of three new antibiotics, thiocillins I, II and III, related to micrococcin P. Studies on antibiotics from the genus Bacillus.", J. Antibiot. (Tokyo) 29,366-374(1976)

Sequence

........10	........20
\|	\|
SCTTCVCTCS	CCTT

Wheel representation

Composition

AA	N°	%	AA	N°	%	AA	N°	%
Ala	0	.00%	Ile	0	.00%	Arg	0	.00%
Cys	6	42.86%	Lys	0	.00%	Ser	2	14.29%
Asp	0	.00%	Leu	0	.00%	Thr	5	35.71%
Glu	0	.00%	Met	0	.00%	Val	1	7.14%
Phe	0	.00%	Asn	0	.00%	Trp	0	.00%
Gly	0	.00%	Pro	0	.00%	Tyr	0	.00%
His	0	.00%	Gln	0	.00%
Total	14

Formula	C₄₉ H₈₆ N₁₄ O₂₂ S₆
Absent amino acids	ADEFGHIKLMNPQRWY
Common amino acids	C
Mass (Da)	1433.89

Net charge	0
Isoelectric point	5.61
Basic residues	0
Acidic residues	0
Hydrophobic residues	1
Polar residues	13
Aliphatic residues	1
Tiny residues	2

Boman Index	-7.93
Hydropathy Index	1.01
Aliphatic Index	20.71
Instability Index	120.33 (unstable)
Half Life	Mammalian : 1.9 hour Yeast : >20 hour E. coli : >10 hour
Extinction Coefficient	0 M^-1 cm^-1
Absorbance 280nm	28.85

Red solid plot : values according to the hydrophobicity scale of Kyte and Doolittle (reference paper).

Yellow dashed plot : Experimentally determined hydrophobicity scale for proteins at membrane interfaces(reference paper).

Green dotted-dashed plot : prediction of transmembrane helices (reference paper). In this scale (unlike the others), more negative values reflect greater hydrophobicity.

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